In Chicago, the boy Jake is interned in a mental institution and his therapist, Dr. Sullivan, does not believe that he is haunted by the ghost of the boy Toshio. When Jake is killed in his cell with all his bones broken, Dr. Sullivan decides to investigate further with open-mind.
Meanwhile, Lisa, who is the sister of the superintendent Max of Jake’s building, steals the key of apartment 305 to have sex with her boyfriend Andy. When she realizes that the spot is a crime scene, she immediately returns to her apartment, where she lives with Max and their sister Rose.
In the meantime, the Japanese Naoko decides to travel from Tokyo to Chicago to stop the curse of her sister Kayako. She meets Lisa and tells that she needs hers and Rose’s help her to stop the fiend of her sister, but Lisa does not accept the offer. When Max is possessed by the evil spirit of Daisuke, Lisa visits Naoko but it may be too late to stop the curse.